Manual of Procedures

Introduction, Interviewing Guidelines, Appointment Letters, Documents, and Alerts

	Visit 1	Visit 2	Visit 3
Introduction	Ch1_Introduction	Visit 2: Introduction	Visit 3:_Introduction
Interviewing and Proxy Interviewing Guidelines	Visit 1: Interviewing Guidelines Visit 1: Proxy Interviewing Guidelines	Visit 2: Interviewing Guidelines	Visit 3: Interview Guidelines
Appointment Letters, Documents, and Alerts	Visit 1: Appointment Letters and Documents Visit 1: Alerts	Visit 2: Appointment Documents LengthTracking_12152014_v5 Visit 2: Alerts Panel 21 Alert Tracking	Visit 3: Appointment Documents Visit 3: LengthTracking Visit 3: Alerts Visit 3: Panel 21_AlertTracking

Recruitment (including Controls)

Visit 1

Visit 2

Visit 3

Visit 1: Recruitment

Visit 1: Control Recruitment

Visit 2: Recruitment

Visit 3: Recruitment

Accompanying Data Collection Forms

01_TS1_TlphnFLoSS1_012508_v6

02_TS2_RelCntctTrackInfo_101006

03_TS1a_TelephoneFamily_032207_v3

04_TS3_PedInfoForm_060206

05_TS1ac_TelephoneControl_032607_v4

06_TS1c_FLSControl_060706

06a_TS1c_FLSControl_062706_PilotUPBU

07_LLFS Response Form_010808_v3

Panel 14_PrtcpContactInfo_021606

05_TS1ac_TelephoneControl_06172014_v1

03_TS1a_TelephoneFamily_06172014_v1

Panel 12 Wrksht_FamilyStrct_030706_v1

Panel 14_PrtcpContactInfo_03122015_v4

Visit 3: 02_TS2-V3_RelCntctTrackInfo_161019_v5

03_TS1a-V3_TelephoneScreener_21022020_v2

05_TS1ac_TelephoneControl_21112019_v4

Panel 14_PrtcpContactInfo_21102019_v1

Obtaining Consent

Visit 1

Visit 2

Visit 3

Manual of Procedures

Visit 1: Obtaining Consent

Vsit 2: Obtaining Consent

Visit 3: Obtaining Consent

Accompanying Data Collection Forms

Panel 1_ConsntTrckFsbilty_031307_v2

Panel 1_ConsntTrckFsbilty_BU_031307_v2

Panel 1_ConsntTrckFsbilty_CU_031307_v2

Panel 1_ConsntTrckFsbilty_UP_032207_v3

Panel 1a_CnsntAssmt_032907_v1

Panel 1b_ProxyCriteria_032907_v1

Panel 1_ConsntTrckFsbilty_BU_01132015_v3

Panel 1_ConsntTrckFsbilty_CU_11212016_v4

Panel 1_ConsntTrckFsbilty_DK_01132015_v2

Panel 1_ConsntTrckFsbilty_UP_01132015_v2

Panel 1a_CnsntAssmt_06032014_v1

Panel 1b_ProxyCriteria_06032014_v1

Visit 3: Panel 1_ConsntTrckFsbilty_all_20012021_v3

Visit 3: Panel 1a_CnsntAssmt_23102019_v1

Visit 3: Panel 1b_ProxyCriteria_23102019_v1

Anthropometry: Blood Pressure, Height, Weight, Ankle Brachial Index

	Visit 1	Visit 2	Visit 3
Manual of Procedures	Visit 1: Antropometric Measures	Visit 2: Anthropometric Measures	Visit 3: Anthropometric Measures
Accompanying Data Collection Forms	Panel 9_BP-Weight_092607_v6	Panel 9_NP_BPWGHT_08012015_v3	Visit 3: Panel 9_ALL_BPWGHT_13102019_v1

Carotid Ultrasound

Visit 1

Visit 2

Visit 3

Manual of Procedures

N/A

Visit 2: Carotid Ultrasound

Visit 3: Carotid Ultrasound

Accompanying Data Collection Forms

N/A

LLFS alert_action_form_2014_11_18

Panel 18 CarotidUltrasound_log_sheet_06022014_v3

Panel18a_LLFS_CQI Form_07072014

Panel18b_LLFS_8_image_carotid IMT wksht_07072014

Visit 3: Carotid alert action form

Visit 3: Carotid CQI form

Visit 3: Carotid 8 image IMT Worksheet

Visit 3: Carotid Log Sheet

Socio-demographic Information


	Visit 1	Visit 2	Visit 3
Manual of Procedures	Visit 1: Socio-Demographic Information	Visit 2: Socio-Demographic Information	Visit 3: SocioDemographic Information
Accompanying Data Collection Forms	Panel 2_SocioDemo_010808_v7 Panel 2_SocioDemo_DK_040207_v5	Panel 2_New_SocioDemo_03132015_v14 Panel 2_New_SocioDemo_DK_03132015_v13 Panel 2_Returning_SocioDemo_03132015_v14 Panel 2_Returning_SocioDemo_DK_03132015_v14 Panel 2a_ProbandGrandchild_03132015_v4	VIsit 3: US Panel 2_All_SocioDemo_12112020_v5 Visit 3: Denmark Panel 2_All_SocioDemo_DK_12112020_v4

Physical Function/ Activities of Daily Living

Visit 1

Visit 2

Visit 3

Manual of Procedures

Visit 1: Physical Function

Visit 2: Physical Function

Visit 3: Physical Function

Accompanying Data Collection Forms

Panel 3_ADLs_050407_v4

Panel 3_New_PhysFunctADLs_03132015_v9

Panel 3_Returning_PhysFunctADLs_03122015_v10

Panel 20 IADL_03132015_v2

Visit 3: Panel 3_ALL_PhysFunctADLs_13102019_v2

Visit 3: Panel 20 IADL_13102019_v1

Cognitive Assessment and Brain Donation

Visit 1

Visit 2

Visit 3

Manual of Procedures

Visit 1: Cognitive Assessment

Visit 2: Cognitive Assessessment

Visit 2: Clinical Dementia Rating

Visit 3: Cognitive Assessment

Visit 3: Dementia Review

Visit 3: Brain Donation

Accompanying Data Collection Forms (Unable to share due to copyright, but tests given are listed)

Panel 7c_Prxy-Bsd Onset Intvw_081607_v2

CDR_Panel_12

Visit 3: Panel 12 CDR

Visit 3: cover letter for brain donation_03102022

Visit 3: Brain Donation FAQ

Visit 3: Brain donation LLFS form

Mood and Personality

Visit 1

Visit 2

Visit 3

Manual of Procedures

Visit 1: Mood and Personality

See New Participant Chapter (not repeated for participants from Visit 1)

Visit 3: Mood and Personality

Accompanying Data Collection Forms

Panel 11_Mood-Personality_040207_v4

Panel 11_CES-D_09162014_v3

Panel 11a-II_NP_NEO_03132015_v7

Panel 11_CES-D_22112019_v1

Panel 11a_NP_NEO_22112019_v2

Medical and Personal History

Visit 1

Visit 2

Visit 3

Manual of Procedures

Visit 1: Medical and Personal History

Visit 2: Medical and Personal History

Visit 3: Medical and Personal History

Accompanying Data Collection Forms

Panel 4_Personal Hx_040207_v3

Panel 5_MedHx_032708_v4

Panel 4_New_PersonalHx_03132015_v7

Panel 4_Returning_PersonalHx_03132015_v8

Panel 5_New_MedHx_03132015_v12

Panel 5_Returning_MedHx_03132015_v12

Panel 4_ALL_PersonalHx_07042021_v4

Panel 5_NewPpt_MedHx_07012021_v3

Panel 5_ReturnPpt_MedHx_17112021_v4

Census Linkage and Pedigree Creation

Visit 1

Visit 2

Visit 3

Manual of Procedures

Visit 1: Census Linkage

Visit 1: Pedigree

Accompanying Data Collection Forms

04_TS3_PedInfoForm_060206

Panel 12 Wrksht_FamilyStrct_030706

Panel 12 Wrksht_FamilyStrct_030706_v1

Physical Performance Measures

	Visit 1	Visit 2	Visit 3
Manual of Procedures	Visit 1: Performance Measures	Visit 2: Performance Measures	Visit 3: Performance Measures
Accompanying Data Collection Forms	Panel 8_Perf Measures_081607_v3	Panel 8_Perf Measures 02052014_v2	Panel 8_Perf Measures 28032023_v8

Spirometry

	Visit 1	Visit 2	Visit 3
Manual of Procedures	Visit 1: Spirometry	Visit 2: Spirometry	Did not perform due to COVID-19
Accompanying Data Collection Forms	Panel 10_Spirometry_092407_v5	Panel 10_Spirometry_041314_v3

Medication Inventory

	Visit 1	Visit 2	Visit 3
Manual of Procedures	Visit 1: Medication Inventory	Visit 2: Medication Inventory	Visit 3: Medication Inventory
Accompanying Data Collection Forms	Panel 6_Med Inventory_072707_v4	Panel 6_Med Inventory_03132015_v2	Panel 6_Med Inventory_06102019_v1

Blood Collection

Visit 1

Visit 2

Visit 3

Manual of Procedures

Visit 1: Blood Collection

Visit 2: Blood Collection

Visit 2: LLFS collection instructions

Bisit 3: Blood Collection

Accompanying Data Collection Forms

Panel 13_Blood Collection_081607_v5

Panel 13_Blood Collection_17062015_v6

Panel 13a_Blood Collection Phantom_03022015_v3

Panel 13_Blood Collection_04092019_v4

Panel 13a_BloodCollectionPhantom_04092019_v2

Panel13b_COVIDsaliva_Brochure_2Panel_LLFS ab saliva

New Participants

Visit 1

Visit 2

Visit 3

Manual of Procedures

N/A

Visit 2: New Participants

See individual chapters

Accompanying Data Collection Forms

Panel 11_CES-D_09162014_v3

Panel 11a-II_NP_NEO_03132015_v7

Panel 12 Wrksht_FamilyStrct_030706_v1

Panel 14_PrtcpContactInfo_03122015_v4

Panel 19-II_NP_HealthHabits_092211_v6

Panel 11_CES-D_22112019_v1

Panel 11a_NP_NEO_22112019_v2

Panel 14_PrtcpContactInfo_21102019_v1

Panel 19_NP_HealthHabits_30102019_v1

OMICS Generation and Quality Control

	Visit 1	Visit 2	Visit 3
Manual of Procedures	N/A	N/A	Ch7a_OMICS_15102024_v4
Accompanying Data Collection Forms

Data Entry and Quality Control

	Visit 1	Visit 2	Visit 3
Data Entry Manual of Procedures	Visit 1: Data Entry	Visit 2: Data Entry	Visit 3: Data Management
Quality Control Manual of Procedures	Visit 1: Quality Control	Visit 2: Quality Control	Visit 3: Quality Control

Long Distance Visit and Transfer Protocol

	Visit 1	Visit 2	Visit 3
Long Distance Visit Manual of Procedures	Visit 1: Long Distant Visits	Visit 2: Long Distant Visits	Visit 3: Long Distant Visits
Transfer Protocol Manual of Procedures	Visit 1: Transfer Protocol

Participant Annual Follow-Up

Visit 1

Visit 2

Visit 3

Manual of Procedures

Visit 1: Participant FU

Ch25b_PhII FollowUp 102009_v5

Ch25c_PhII FollowUp 092211_v2

Visit 2: Participant Follow-up

Visit 2: Ch25b_PhII FollowUp

Visit 3: Annual Follow Up

Accompanying Data Collection Forms

Panel 16_FU Qstnaire_021108_v11

Panel 16_FU Qstnaire_DK_011008_v10a

Phase II

Panel 5-II_MedHx_052109_v3

Panel 6-II_Med Inventory_051209_v2

Panel 7b-II_TICS_072009_v7

Panel 7d-II_Dementia_012610_v20

Panel 11a-II_NEO_110609_v5

Panel 14-II_PrtcpContactInfo_061109_v1

Panel 16a-II_FU Qstnaire_DK_050709_v1

Panel 16-II_FU Qstnaire_061109_v4

Panel 18-II_Decedent Intrv_012710_v9

Panel 19-II_HealthHabits_092211_v5F

Panel 16_FU Qstnaire_07062018_v12

Panel 5-II_NP_MedHx03132015_v6

Panel 7b-II_TICS_08262014_v9

Panel 7d-II_Dementia_02282014_v23

CDR_Panel_12

Panel 14_PrtcpContactInfo_03122015_v4

Panel 18-II_Decedent Intrv_07Sep2016_v14

Panel 16-FU_FU Qstnaire_02112021_v9

Panel 5-FU_MedHx_22112019_v1

Panel 7b_TICS_22112019_v1

Panel 7d_Dementia_22112019_v2

Visit 3: Panel 12 CDR

Panel 14_PrtcpContactInfo_21102019_v1

Panel 18-FU_Decedent Intrv_22112019_v2

Presentations and Publications/ Ancillary Studies

	Visit 1	Visit 2	Visit 3
P&P Policy Manual of Procedures	Visit 1: P&P Policy	Visit 2: P&P Policy	Ch21-P&P_04082018_v6
Ancillary Studies Manual of Procedures	Visit 1: Ancillary Study Policy	Visit 2: Ancillary Study	Visit 3: Ancillary Studies