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LLFS News & Media

LLFS News & Media

1.    Perceived Physical Fatigability Predicts All-Cause Mortality in Older Adults.[28]

Glynn NW, Gmelin T, Renner SW, Qiao YS, Boudreau RM, Feitosa MF, Wojczynski MK, Cosentino S, Andersen SL, Christensen K, Newman AB.

 (This paper has an Altmetrics score of 243; has already been cited 5 times; conducted 2 radio interviews, 2 print articles, 26 tweets, and picked up by 29 news outlets)


In reference to the Long Life Family Study, generally:


Related to: Fagan, E, Sun, F, Bae, H, Elo, I, Andersen, S, Lee, J, Christensen, K, Thyagarajan, B, Sebastiani, P, Perls, T, Honig, L, Schupf, N. Telomere length is longer in women with late maternal age. Menopause: May 2017, 24 (5) 497-50. PMID: 27922939 PMCID: PMC5403597. 



Related to: Bae H, Gurinovich A, Malovini A, Atzmon G, Andersen SL, Villa F, Barzilai N, Puca A, Perls TT, Sebastiani P. Effects of FOXO3  polymorphisms on survival to extreme longevity in four centenarian studies. The Journal of Gerontology: Series A, 2017 Oct; 72(11):1453-1464, PMC5861876. 


  • Genetic influence on aging into the 90s but not beyond — ScienceDaily
    • Jul 18, 2017 – Effects of FOXO3 polymorphisms on survival to extreme longevity in four centenarian studies. The Journals of Gerontology: Series A, 2017; DOI: …
  • Association of the FOXO3A Locus with Extreme Longevity in a …
    • We validated the association of FOXO3A polymorphisms with extreme longevity in males from the Southern Italian Centenarian Study. Particularly, rs2802288, a …
  • New findings suggest a genetic influence on aging into the 90s but not …
    • Jul 18, 2017 – … The Longevity Genes Project at Albert Einstein College of Medicine; and the National Institutes on Aging-funded Long Life Family Study.
  • New findings suggest a genetic influence on aging into the 90s but not …
    • July 18, 2017. CORVALLIS, Ore. – Variants of a gene thought to be linked to longevity appear to influence aging into the 90s, but do not appear to affect exceptional longevity, or aging over 100, a new study has found.


Related to: Sebastiani P, Thyagarajan B, Sun F, Schupf N, Newman AB, Montano M, Perls TT.  Biomarker signatures of aging.  Aging Cell 2017.  pp1-10.  Doi: 10.111/acel.12557.PMID: 28058805. PMCID: PMC5334528. 


Related to: Paola Sebastiani, Anastasia Gurinovich, Harold Bae, Stacy Andersen, Alberto Malovini, Gil Atzmon, Francesco Villa, Aldi T. Kraja, Danny Ben-Avraham, Nir Barzilai, Annibale Puca, Thomas T. Perls. Four Genome-Wide Association Studies Identify New Extreme Longevity Variants. The Journals of Gerontology: Series A, 2017; DOI: 10.1093/gerona/glx027


  • New genetic variants associated with extreme old age
    • April 27, 2017 – New genetic variants associated with extreme old age. The search for the genetic determinants of extreme longevity has been challenging, with the prevalence of centenarians (people older than 100) just one per 5,000 population in developed nations. But a recently published study that combines four studies of extreme longevity, has identified new rare variants in chromosomes 4 and 7 associated with extreme survival and with reduced risks for cardiovascular and Alzheimer’s disease.

Related to: Pedersen JK, Elo ITSchupf NPerls TTStallard EYashin AIChristensen K. The Survival of Spouses Marrying Into Longevity-Enriched Families. J Gerontol A Biol Sci Med Sci. 2017 Jan;72(1):109-114. Epub 2016 Aug 18.


Related to: Sun F, Sebastiani P, Schupf N, Bae H, Andersen SL, McIntosh A, Abel H, Elo IT, Perls TT. Extended maternal age at birth of last child and women’s longevity in the Long Life Family Study. Menopause. 2015 Jan; 22(1)”26-31. Doi: 10.1097/GME.0000000000000276. PMCID: PMC4270889. PMID: 24977462.


Study examines cognitive impairment in families with exceptional longevity | EurekAlert! Science News
Public Release: 6-MAY-2013 A study by Stephanie Cosentino, Ph.D., of Columbia University, New York, and colleagues examines the relationship between families with exceptional longevity and cognitive impairment consistent with Alzheimer’s disease.

Chromosomal Location of Exceptional Memory Identified. Interview with: Sandra Barral Rodriguez, Ph.D. (Common genetic variants on 6q24 associated with exceptional episodic memory performance in the elderly. Barral S, et al. JAMA Neurol 2014;71:1514-1519).

Those with more lifespan also have more healthspan. Researchers compared the health-spans of older generation subjects of the Long Life Family Study (LLFS) to controls without family history of longevity and to centenarians of the New England Centenarian Study (NECS) using Bayesian parametric survival analysis.


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